Deferrer message within 'mailq': what's the meaning?

Hi.

I've created a PHP software to handle a mailing list with 3000+ addresses,
but my server crashes suddenly because (I think) '/var/spool/mqueue' is full.

If I perform 'mailq', I get 110 mails in queue, most of them with this messages:
Code:
8BITMIME   (Deferred: 451 <xx@domain.com>... Requested mail action)
...
8BITMIME   (reply: read error from mx2.mail.yahoo.com.)
...
8BITMIME   (Deferred: Connection timed out with mail.xx.com.)
...
8BITMIME   (Deferred: 450 Client host rejected: cannot find your hostnam)
...
8BITMIME   (Deferred: 451 mta167.mail.re4.yahoo.com Resources temporaril)
..
8BITMIME   (Deferred)
Which is the meaning of this messages? Can I manage them to make my process more
fluid? Can I remove them?

I've got 90 not-sent mails now in my 'mqueue'. Could it affect to the performance of
my server?

Thank you very much.

 

 

 

 

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